The logarithmic instellation (normalized to Earth) versus escape velocity of 564 cataloged exoplanets. JWST targets as of Cycle 5 are highlighted in red, while our π Men c measurements and propagated uncertainties are in orange. Earth’s position on this relation is designated as a blue star. The size of each point corresponds to its transmission-spectroscopy metric (TSM), a value proportional to the expected signal-to-noise ratio of a transmission spectra. π Men c occupies a unique space within escaping atmospheres while possessing a TSM value comparable to JWST targets.