The solid curve shows the theoretical two-sided binomial cumulative distribution function TCDF(p) for a cube set with R = 100 in Array 7. The probability of obtaining an asymmetry equal to or larger than that observed for this set is given by p_frac = TCDF(p). The dashed line represents the corresponding TCDF for the normal distribution. In the binomial case, the curve deviates from the normal distribution due to its discrete and finite nature.